在耐火性/复发性多发性骨髓瘤患者中,CAR-T治疗失败后的救援治疗策略
Chao Min1, Xiong Zhong2, Yue Cui1
1Department of Hematology, 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxin, China.
Frontiers in pharmacology
|April 1, 2025
概括
多发性骨髓瘤 (MM) 治疗已取得进展,但CAR-T疗法可能会失败. 本综述探讨了CAR-T失败的原因,并讨论了复发性/耐药性MM患者的救援策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 血液学 血液学 血液学
背景情况:
- 多发性骨髓瘤 (MM) 治疗已通过蛋白酶体抑制剂和免疫调节药物取得进展.
- 尽管有进展,MM仍然无法治愈,需要新的治疗方法.
- 与idecabtagene vicleucel (ide-cel) 一样,化学抗原受体T细胞 (CAR-T) 疗法现在可用于复发性/耐药性MM (R/R MM).
研究的目的:
- 审查导致R/RMM患者CAR-T治疗失败的因素.
- 讨论在CAR-T治疗失败后可能的救援治疗策略.
- 为在CAR-T后的环境中管理治疗失败提供建议.
主要方法:
- 关于R/RMM的CAR-T治疗研究的文献综述.
- 分析导致CAR-T疗法耐药性的机制.
- 综合现有和新兴的救援处理选项.
主要成果:
- 在R/RMM中,CAR-T疗法失败可能是由于抗原损失,T细胞耗尽和瘤免疫微环境造成的.
- 对于在CAR-T治疗后复发的患者,正在研究几种救援策略.
- 优化救援疗法需要了解抵抗机制和量身定制治疗方法.
结论:
- 在R/R MM患者中,救援疗法对于经历CAR-T后复发的MM患者至关重要.
- 需要进一步的研究来开发有效的CAR-T后治疗方案.
- 解决CAR-T衰竭对于改善R/RMM患者的治疗结果至关重要.
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