在登革热中,氧化应激诱导的肝损伤在肥胖患者中加剧
Heshan Kuruppu1, Maneshka Karunananda1, Chandima Jeewandara1
1Allergy, Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
medRxiv : the preprint server for health sciences
|April 1, 2025
概括
肥胖与高肝酶和登革热患者的炎症有关. 脂质过氧化标志物 (4-HNE,MDA) 在登革热病原发生过程中表现出复杂的作用,这表明了潜在的治疗点.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖和糖尿病是已知的严重登革热的危险因素.
- 关于肥胖对肝功能障碍和急性登革热中氧化应激的影响的数据有限.
研究的目的:
- 研究不同肥胖程度的登革热患者的肝功能障碍,氧化应激和炎症标志物.
- 探索在急性登革热中肥胖,肝损伤和氧化应激之间的联系.
主要方法:
- 招募了577名患有急性疾病 (≤4天) 的成年登革热患者.
- 测量了肝酶 (AST,ALT),C反应蛋白,费里丁,4-氨 (4-HNE) 和马隆迪化物 (MDA).
- 评估人体测量指标,包括BMI和腰围.
主要成果:
- 中心肥胖和较高的BMI与升高的AST,ALT,CRP和费里丁相关.
- 4-氨酸 (4-HNE) 与AST/ALT水平增加,而氨酸 (MDA) 则下降.
- 较年轻,较瘦个体的MDA水平较高,与费里丁相反相关.
结论:
- 肥胖与增加肝脏功能障碍和登革热炎症有关.
- 4-HNE和MDA在登革热病原发生过程中表现出不同的作用,需要进一步调查.
- 了解这些途径可能会为登革热治疗确定新的治疗点.
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