早期视觉皮层的结构共变与PTSD症状有负面关联:ENIGMA PTSD工作组的一项大型分析
Nathaniel G Harnett1,2, Soumyaa Joshi1, Poornima Kumar1,2
1Division of Depression and Anxiety, McLean Hospital, Belmont, MA, USA.
medRxiv : the preprint server for health sciences
|April 1, 2025
概括
早期视觉皮层中的结构共变与创伤后应激障碍 (PTSD) 症状有关. 这一发现表明,在多种多样的创伤暴露个体中,PTSD的潜在神经脆弱性标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 识别创伤后应激障碍 (PTSD) 的神经特征对于个性化治疗至关重要.
- 新兴研究表明,早期视觉区域的结构共变性与PTSD发展之间存在联系.
- 需要进行大规模的研究来确认这种神经特征是否起到脆弱性标记的作用,可能会在创伤暴露之前发生.
研究的目的:
- 研究早期视觉皮层结构共变性与PTSD症状或感知压力之间的关联.
- 在一个更大的,多样化的样本中验证先前识别的多式联络模式.
- 探索视觉皮层结构共变的潜力,作为PTSD脆弱性的生物标志物.
主要方法:
- 对ENIGMA-PTSD (n=2,814) 和人类连接组项目 - 年轻成年人 (HCP-YA) (n=890) 数据集的分析.
- 利用了从创伤幸存者观察到的多式模式中得出的结构共变性.
- 采用线性混合效应模型来评估与PTSD症状和感知压力的关联.
主要成果:
- 在ENIGMA-PTSD数据集中,在早期视觉皮层共变负载和PTSD症状之间发现了显著的负相关性.
- 即使在对儿童虐待进行控制后,这种关联仍然很强大.
- 在HCP-YA数据集中没有观察到与抑郁症状或感知压力的显著关系,支持PTSD症状特异性.
结论:
- 早期视觉皮层的结构共变性是多样化的创伤幸存者的国际样本中PTSD症状的强有力的关联神经标志物.
- 需要进一步的研究来阐明这些视觉皮层改变背后的具体机制.
- 了解这些结构变化可能会增强我们对创伤后精神病理学的理解.
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