在乌干达女性酒吧工作者中艾滋病毒血清流行,发病率和病毒抑制:基于人口的研究
Xinyi Feng1, Gertrude Nakigozi2, Eshan U Patel3
1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
medRxiv : the preprint server for health sciences
|April 1, 2025
概括
乌干达的女性酒吧工作者 (FBW) 面临着显著更高的艾滋病毒负担和感染风险. 有针对性的艾滋病毒预防策略和服务对于减少FBW及其合作伙伴之间的传播至关重要.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 在非洲,女性酒吧工作者 (FBW) 是艾滋病毒感染风险较高的人群.
- 关于非洲环境中的FBWs中艾滋病毒负担的有限的人口级数据存在.
研究的目的:
- 确定乌干达的FBW中艾滋病毒负担和感染风险.
- 为了比较FBW和非FBW之间的HIV流行,发病率和病毒抑制.
主要方法:
- 利用了乌干达南部Rakai社区队列研究的五轮调查数据 (2011-2020年).
- 使用Poisson回归模型,在FBW和非FBW之间比较艾滋病毒阳性,事件感染和病毒抑制.
主要成果:
- 与非FBW相比,FBW显示出显著更高的HIV血清流行率 (51.9%与18.5%) 和发病率 (2.49与0.87每100人/年).
- 在FBW中,艾滋病毒病毒病的流行率是FBW的1.69倍.
- 艾滋病毒阴性FBW中对PrEP的认识很高,但吸收和当前使用很低.
结论:
- 乌干达的FBW经历了显著更高的艾滋病毒负担和获取风险.
- 定制的艾滋病毒预防策略,优先考虑为FBW提供服务,对于减少艾滋病毒发病率至关重要.
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