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Dietz Andreas¹, Eckel Hans², Alexander deVries³

¹Hals-Nasen-Ohren-Universitätsklinik, Leipzig, Germany.

Frontiers in oncology

|April 1, 2025

概括

喉器官保存 (LOP) 为喉癌提供了使用化疗辐射的非手术选择. 确定理想的候选人仍然具有挑战性,救援手术通常是必要的,但复杂的.

科学领域:

在瘤学瘤学.
头部和部手术头部和部手术
医学治疗策略医疗治疗策略

背景情况:

喉器官保存 (LOP) 是一种用于喉癌的非手术方法,主要使用化疗 (CRT) 或新辅助化疗,然后进行放射治疗 (NCT+RT).
目前选择LOP患者的标准尚不清楚,导致患者偏好,外科医生经验和机构因素影响决策.
一个LOP的重大缺点是由于持续的瘤,经常需要进行救援手术,这可能导致严重的并发症,并且并不总是可行的.

研究的目的:

在喉癌治疗中审查喉器官保存 (LOP) 的现状.
讨论LOP患者选择的挑战和救援手术的影响.
探索新兴的新辅助策略,包括免疫疗法,用于头癌.

主要方法:

关于使用多模式治疗来保护喉器官 (LOP) 的当前文献和临床实践的综述.
分析新辅助化疗 (NCT) 在选择LOP响应者的作用及其对整体存活率的影响.
探索头癌新辅助治疗概念的最新进展,包括免疫检查点抑制剂.

主要成果:

新辅助化疗后进行放射治疗 (NCT+RT) 用于选择LOP的响应者,但通常需要进行救援手术,并与严重的并发症相关.
单独的新辅助化疗 (NCT) 没有证明改善整体存活率,并且在LOP选择之外的应用有限.
新辅助方法,包括与免疫检查点抑制剂的组合,在外科手术期间的透口外科手术治疗概念中显示出希望.

结论:

优化患者选择喉器官保存 (LOP) 对于最大限度地减少复杂的救援手术的需要至关重要.
虽然NCT+RT有助于选择LOP候选人,但其局限性需要进一步研究替代的新辅助策略.
新兴的新辅助疗法,特别是那些涉及免疫治疗的疗法,为改善头癌的治疗结果提供了新的途径.

关键词:

头部和部癌症是什么意思诱导化疗是一种诱导化疗.喉切除术是指进行喉切除术.喉器官保存喉器官保存没有手术的治疗.

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