在美国人口中,泛免疫-炎症值与失脂症之间存在关联
Yu Yan1, Shanshan Jia1, Xingwei Huo2
1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in endocrinology
|April 1, 2025
概括
全免疫-炎症值 (PIV) 与失脂血症积极相关. 在年轻,超重的个体中,这种风险更高,这表明PIV是失脂症的潜在指标.
科学领域:
- 心血管健康 心血管健康
- 炎症生物标志物 炎症生物标志物
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 脱脂症是心血管疾病的主要危险因素.
- 全免疫炎症值 (PIV) 是一种反映系统性炎症的新兴生物标志物.
- 了解炎症和代谢健康之间的新兴关联对于预防策略至关重要.
研究的目的:
- 为了研究泛免疫炎症值 (PIV) 和失脂症之间的关联.
- 通过使用大型,具有全国代表性的数据集来探索这种关系.
- 评估PIV与其他炎症标志物相比的预测值.
主要方法:
- 使用国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 进行了加权多变量逻辑回归,限制立方线 (RCS) 和值效应分析.
- 接收机运行特征 (ROC) 曲线分析用于比较评估.
主要成果:
- 在PIV和脱脂症之间发现了显著的积极关联 (OR:1.13;95%CI:1.01-1.25)
- 在PIV的最高四分之一的参与者显示出显著更高的血脂不良的风险 (OR: 1.37;95% CI: 1.05-1.80).
- 观察到一个反转的J形关系,在PIV=9.192的拐点;年龄和BMI修改了这种关联.
结论:
- PIV显著与失脂血症的风险增加有关.
- PIV和脂质不良症之间的关系因年龄和BMI而有所改变.
- PIV的预测值与失脂症的全身免疫炎症指数 (SII) 的预测值相当.
相关概念视频
Blood Studies for Cardiovascular System III: Serum Lipid Profile
108
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
108
Lipids: Dietary Sources and Requirements
595
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
595
Inflammation
52.0K
Overview
52.0K
Cholesterol: Significance and Regulation
462
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
462
Chronic Pancreatitis I: Introduction
56
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
56
Psychoneuroimmunology: Cardiovascular Disease
21
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
21


