儿童急性B型淋巴细胞白血病中的编程细胞死亡-1和编程细胞死亡配体-1:作为生物标志物的表达和意义
Ahmed Ahmed Allam1, Heba A Ahmed1, Mohammad Ahmad Hassan2
1Department of Clinical Pathology, Sohag University Faculty of Medicine, Sohag, Egypt.
International journal of laboratory hematology
|April 1, 2025
概括
在儿童B型急性淋巴细胞白血病 (B-ALL) 患者的诊断时,编程死亡-1 (PD-1) 和编程死亡连接物-1 (PDL-1) 的水平升高. 较低的PD-1和PDL-1水平与缓解率的增加相关,表明治疗潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科瘤学 儿科瘤学
- 分子生物学分子生物学
背景情况:
- 急性B型淋巴细胞白血病 (B-ALL) 是一种重要的儿科癌症.
- 编程死亡-1 (PD-1) 和编程死亡连接体-1 (PDL-1) 是关键的免疫检查点蛋白.
- 了解B-ALL中的PD-1/PDL-1表达可能会揭示治疗点.
研究的目的:
- 评估新诊断的儿科B-ALL中的PD-1和PDL-1表达.
- 为了评估6个月治疗后PD-1和PDL-1表达的变化.
- 探索PD-1和PDL-1作为B-ALL中的预测生物标志物的潜力.
主要方法:
- 招募了50名新诊断的B-ALL患者和30名健康对照.
- 在诊断时和治疗后6个月收集骨髓或外周血液样本.
- 使用流细胞计量来量化PD-1,PDL-1和CD3的表达.
主要成果:
- 在B-ALL患者中,与诊断时的对照人群相比,观察到PD-1和PDL-1水平升高 (p <0.05).
- 在6个月的治疗后,PD-1和PDL-1的水平显著下降.
- 较高的PD-1/PDL-1表达与较低的缓解率相关,而减少的表达与缓解率的增加有关.
结论:
- 在诊断时,PD-1和PDL-1在儿科B-ALL上升调节,并随着治疗而下降.
- PD-1和PDL-1表达水平与治疗反应和缓解率有关.
- 调节PD-1/PDL-1通路可能是B-ALL的一种有前途的治疗策略.
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