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Updated: May 16, 2025

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淋巴细胞内皮链氨基酸代谢缺陷破坏心脏淋巴完整性并驱动HFpEF

Xiong Guo1, Chong Huang1, Ling Zhang1

  • 1Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China (X.G., C.H., L.Z., G.H., X.C., F.S., T.L., Z.C., C.L., Y.G., W.Y., Y.X., S.W., H.L., Z. Liu, Z. Lin, X.W., Z.W., F.Z., L.T.).

Circulation
|April 1, 2025
PubMed
概括

心脏淋巴功能受损,与淋巴内皮细胞 (LEC) 中缺陷的分支链氨基酸 (BCAA) 代谢有关,显著导致心力衰竭 (HFpEF). 恢复BCAA代谢和淋巴完整性为HFpEF提供了潜在的治疗方法.

关键词:
分支链氨基酸内皮细胞心脏衰竭淋巴血管发生血管内皮生长因子受体-3

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