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微RNA作为动物生理和压力处理的生物标志物

Montaser Elsayed Ali¹, Fatimah A Al-Saeed², Ahmed Ezzat Ahmed²

¹Department of Animal Productions, Faculty of Agriculture, Al-Azhar University, Assiut, Egypt.

Reproduction in domestic animals = Zuchthygiene

|April 1, 2025

概括

微RNAs (miRNAs) 是动物繁殖的关键生物标志物,调节基因表达并对热应激等环境因素作出反应. 了解它们的机制可以帮助预防生殖障碍.

科学领域:

分子生物学分子生物学
动物繁殖动物繁殖
生物标志物发现发现

背景情况:

自1993年以来,微RNA (miRNA) 已成为动物生物标志物.
它们在基因表达,细胞信号传递和组织稳定方面的作用使它们具有价值.
人们对使用miRNA来监测生殖表现和动物福利日益感兴趣.

研究的目的:

审查在热应激下动物繁殖中的miRNA调节机制.
突出miRNAs作为生殖生理学生物标志物的潜力.
帮助预防和治疗精子生成障碍.

主要方法:

关于动物繁殖中的miRNA研究的文献综述.
分析miRNA在基因表达调节中的作用.
检查环境的影响,特别是热应激,对生殖性能.

主要成果:

miRNAs 作为环境条件和生殖结果之间的关键中间体.
它们在生殖系统和胚胎发育,受精和内分泌学中起着重要作用.
miRNAs对于监测热应激等压力条件下的动物福利至关重要.

结论:

了解热应激下的miRNA功能对于改善生殖生理学至关重要.
向miRNA可以帮助管理和预防生殖障碍.
miRNAs为增强动物繁殖研究和应用提供了一个有希望的途径.

关键词:

生物标志物生物标志物这是一种性腺激素 (gonadotropin).这是一个小RNARNA.摄影周期的摄影周期在生殖生殖的过程中.杂动物杂动物压力就是压力,压力就是压力.

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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...