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与代谢功能障碍相关的脂肪性肝病和肠道微生物组:致病性见解和治疗创新
Bernd Schnabl1,2, Christopher J Damman3, Rotonya M Carr3
1Department of Medicine, Division of Gastroenterology, UCSD, San Diego, California, USA.
The Journal of clinical investigation
|April 1, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 是由肠道微生物组的变化和肠道屏障功能受损所驱动的. 了解这些相互作用可以为MASLD带来新的基于微生物的疗法.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个普遍存在的全球健康问题.
- MASLD的进展涉及从肥胖症到肝硬化的阶段,受到不断变化的致病机制的影响.
研究的目的:
- 审查肠道微生物及其代谢物在MASLD病变发生中的作用.
- 探索肠道屏障功能,失生症和MASLD进展之间的相互作用.
- 讨论对MASLD潜在的微生物治疗策略.
主要方法:
- 文献综述侧重于MASLD中的肠道微生物组合 (细菌,病毒,真菌).
- 对关键代谢物 (乙醇,胆酸,SCFA) 的分析,这些代谢物与疾病进展有关.
- 检查肠道屏障的完整性及其与失生症的关系.
主要成果:
- 肠道屏障和肠道失生症的破坏协同促进MASLD的发病和进展.
- 特定的微生物群落和代谢物显著影响MASLD轨迹.
- 肠道屏障功能的改变是MASLD病原体的核心.
结论:
- 准肠道微生物组和增强肠道屏障功能为MASLD提供了有前途的治疗途径.
- 前生物,益生菌,后生物和微生物代谢物代表了潜在的MASLD治疗方法.
- 对宿主-微生物-代谢物相互作用的进一步研究对于开发有效的MASLD疗法至关重要.
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