床上用品和早期婴儿喘息:一个随机对照试验
Caroline Halley1, Janice Kang1, Phillipa Barnes1
1Department of Medicine, University of Otago Wellington, Wellington, New Zealand.
概括
这项随机试验没有发现使用合成,羊毛或羽毛床单的婴儿喘息的差异. 父母避免在有风险的儿童中使用羽毛床,这可能解释了之前的观察性研究结果.
科学领域:
- 儿科 儿科 儿科
- 环境健康 环境健康
- 过敏和免疫学 过敏和免疫学
背景情况:
- 观察性研究表明,床上用品和儿童喘息之间存在联系.
- 合成床上用品与喘息增加有关,而羽毛床上用品与喘息减少有关.
研究的目的:
- 为了测试羽毛床铺减少婴儿喘息的假设.
- 调查合成,羊毛和羽毛床铺对幼儿早期呼吸系统健康的影响.
主要方法:
- 一个三臂,并行,随机的试验,涉及460名婴儿在新西兰的惠灵顿.
- 从3个月到2岁的婴儿被分配合成,羊毛或羽毛睡袋.
- 喘息,呼吸系统参数和亚托皮状态在2年后被评估.
主要成果:
- 在床上用品组之间没有发现报告或医生诊断的喘息的显著差异.
- 与合成材料相比,使用羽毛材料的儿童在GP手术中出现了明显增加的喘息率 (RR 2.00,95% CI:1.14,3.52).
结论:
- 这项研究不支持之前的观察结果,这些发现将合成床单与更高的喘息率或羽毛床单与早期儿童的呼吸率较低联系起来.
- 选择偏见,即有风险儿童的父母避免羽毛床铺,可能解释了与观察性研究的差异.
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