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关于在资源较少的环境中治疗多发性硬化症的基本药物的建议
Deanna Saylor1, Nick Rijke2, Jennifer McDonell3
1Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Medicine, University Teaching Hospital, Lusaka, Zambia.
针对低资源环境制定了对多发性硬化症 (MS) 基本治疗方法的建议. 该小组确定了关键的疾病修饰疗法 (DMT),以改善全球MS患者的获取和治疗结果.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种中枢神经系统脱髓化疾病,在年轻人中导致残疾.
- 在缺乏资源的环境中,对多发性硬化症的疾病修饰疗法 (DMT) 的获取是有限的.
研究的目的:
- 为了在低资源环境中为MS治疗建立最低必需的DMT.
- 确保平等地获得有效的多发性硬化症治疗方法.
主要方法:
- 召开了一个国际小组,包括患者和医疗保健专业人员.
- 用标准化的GRADE协议审查了DMT的证据,考虑了益处,危害,成本效益和在资源不足的情况下的可行性.
主要成果:
- 对于复发性多发性硬化症,推的DMT包括ocrelizumab,cladribine,fingolimod,dimethyl fumarate,interferon beta和glatiramer acetate. 对于复发性多发性硬化症,推的DMT包括ocrelizumab,cladribine,fingolimod,dimethyl fumarate,interferon beta和glatiramer acetate. 对于复发性多发性硬化症,推的DMT包括ocrelizumab,cladribine,fingolimod,dimethyl fumarate,interferon beta和glatiramer acetate. 对于复发性多发性硬化症,推的DMT包括ocrelizumab,cladribine,fingolimod,dimethyl fumarate,interferon beta和glatiramer acetate.
- 对于渐进的MS,推的DMT包括rituximab,ocrelizumab,glatiramer乙酸,fingolimod和干扰素β.
结论:
- 已经确定了低资源环境中MS必需的DMT.
- 建议基于全面的证据和上下文因素,旨在改善全球多发性硬化症护理.
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