满足多发性硬化症患者的体力活动指南减少疲劳严重程度和影响:随机临床试验的系统审查和元分析
Libak Abou1,2, Tanner Murphy3, Ethan Truong4
1Department of Physical Medicine & Rehabilitation, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109, United States.
Physical therapy
|April 1, 2025
概括
定期体育活动显著减少了多发性硬化症 (MS) 患者的疲劳. 坚持每周150分钟的指导方针或特定的有氧和抵抗训练会通过减少疲劳严重程度和影响来改善生活质量.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 运动科学 运动科学
背景情况:
- 疲劳是多发性硬化症 (MS) 的普遍和衰弱的症状.
- 它会对生活质量产生负面影响,导致跌倒,认知问题和功能限制.
- 定期体育活动是MS患者推的治疗策略.
研究的目的:
- 评估体育活动干预措施的效果,符合MS中关于疲劳的指导方针.
- 为了将这些干预措施的效果大小与疲劳指标的临床重要差异最小值进行比较.
主要方法:
- 随机临床试验 (RCT) 的系统审查和元分析.
- 在多个数据库 (PubMed,Embase等) 进行了搜索. 在2024年10月之前.
- 包括符合体力活动指南的RCT和评估疲劳;评估偏差风险和证据质量 (GRADE).
主要成果:
- 包括22个RCT (920名参与者);17个在元分析中.
- 坚持指导方针的干预措施≥4周显著降低了疲劳严重程度 (SMD=-1.46) 和影响 (MD=-11.88至 -21.08).
- 效果大小超过了临床上重要的最小差异,表明临床相关性,尽管证据质量非常低到中等.
结论:
- 身体活动指导方针,包括每周150分钟或综合有氧/抵抗训练,显著减少MS相关的疲劳.
- 这种疗法在疲劳严重程度和影响方面提供了临床上有意义的改善.
- 遵守这些指导方针可以提高MS患者的生活质量.
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