肺部康复中的联合体育炼在慢性阻塞性肺部疾病中不会改变内皮功能和血管结构:一项随机临床试验
Talmir Nolasco1, Renata Figueiredo, Priscila Zanella
1Author Affiliations: Programa de Pós-Graduação em Ciências Pneumológicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil (Drs Nolasco, Figueiredo, Zanella, Porcher, Gass, and Knorst); Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil (Dr Hauck); and Pulmonology Service, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil (Dr Knorst).
肺部康复改善了COPD症状,运动能力和生活质量. 虽然内皮功能没有改变,但运动对心血管风险因素,如血压和C反应性蛋白,产生了积极的影响.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 运动生理学 运动生理学
背景情况:
- 慢性阻塞性肺病 (COPD) 与显著的心血管疾病相关.
- 内皮功能障碍是COPD患者常见的并发症.
- 像肺部康复 (PR) 这样的运动干预措施对于管理COPD症状和改善生活质量至关重要.
研究的目的:
- 研究一个为期8周的肺康复 (PR) 计划对COPD患者内皮功能和心血管风险因素的影响.
- 为了比较PR与常规护理对各种生理和临床参数的影响.
主要方法:
- 40名COPD患者被随机分配到8周的PR计划或常规护理组.
- 评估的参数包括内皮功能,脚-手臂指数,心血管风险得分,血压,葡萄糖,脂质和C反应蛋白的流媒扩张 (FMD).
- 症状负担,运动能力和生活质量在基线和干预后被评估.
主要成果:
- PR显著改善了COPD症状,运动能力和生活质量 (P < .005).
- 用口病测量的内皮功能在PR后没有显著改善 (P = .87).
- PR导致C反应蛋白,甘油三和葡萄糖的显著降低,以及心血管风险评分,血压和脚-手腕指数的改善 (P < .005).
结论:
- 肺部康复有效地提高了COPD患者的症状,运动能力和生活质量.
- 虽然PR没有改善内皮功能 (FMD),但它积极调节了关键的心血管风险因素.
- PR为心肺呼吸能力提供了显著的好处,并降低了COPD患者的全身心血管风险.
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