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在工业生物工艺监测中用于高通量代谢物分析的定量H NMR优化

Yingting Shi1, Yuxiang Wan2, Yiru Wang3

  • 1Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

Analytical and bioanalytical chemistry
|April 1, 2025
PubMed
概括

本研究引入了一种用于生物过程监测的快速定量1H NMR (qNMR) 方法. 优化的技术显著减少了分析时间,同时保持了对代谢物量化的高准确性.

关键词:
1H qNMR 的时间.生物过程监测监控在CHO细胞培养中,MAb 的生产生产.更多的CRM-ALSS在 OPLS-DA 的基础上.

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