丁酸盐通过减少绝经后妇女的肠道泄漏来改善握手强度和身体表现,这是一个随机对照试验
Rizwan Qaisar1,2,3, Hina Zuhra4, Asima Karim5
1Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, 27272, United Arab Emirates. rqaisar@sharjah.ac.ae.
European journal of nutrition
|April 1, 2025
概括
酸盐补充剂通过减少肠道泄漏生物标志物,改善了绝经后妇女的肌肉强度和身体表现. 这表明丁酸盐可能会防止与更年期相关的肌肉衰退.
科学领域:
- 老年学是一门学科.
- 营养科学 营养科学
- 肌肉生理学 肌肉生理学
背景情况:
- 更年期与肌肉损伤和身体衰退有关.
- 对于这些变化的机制和干预措施尚不清楚.
- 肠道泄漏是绝经后身体损害的一个潜在因素.
研究的目的:
- 调查外源性丁酸盐对绝经后妇女骨肌肉和体力能力的影响.
- 探索肠道泄漏作为绝经相关肌肉损失机制的作用.
- 评估丁酸盐对肠道完整性和炎症生物标志物的影响.
主要方法:
- 一项随机对照试验,涉及绝经后妇女 (安慰剂和丁酸盐组) 和绝经前对照组.
- 丁酸盐组接受了酸盐 (570毫克/天) 12 周.
- 测量包括肠道泄漏的血佐努林和脂多糖结合蛋白 (LBP),手握强度 (HGS),步行速度和身体能力的短物理性能电池 (SPPB).
主要成果:
- 绝经后的女性比绝经前的对照表现出更高的zonulin和LBP,以及较低的体力表现.
- 在绝经后的妇女中,丁酸盐的使用显著降低了诺林和LBP水平.
- 丁酸盐改善了HGS和SPPB的得分,与减少的ゾ努林和LBP相关,还减少了炎症和氧化应激.
结论:
- 外源性丁酸盐在绝经后的女性中显示出肌肉保护作用,这可能是通过肠道粘膜修复的介导.
- 酸盐补充剂可能是一个可行的干预措施,以减轻与更年期相关的肌肉损害.
- 需要进一步的研究,以充分阐明酸盐在这个人群中的益处机制.
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