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菲塞丁可以缓解西斯普拉丁诱导的外围神经病变:一种行为和免疫组织化学研究

Cansel Adıgüzel¹, Caner Yildirim², Sena Çevik¹

¹Department of Physiology, Faculty of Medicine, Gaziantep University, Gaziantep, 27310, Turkey.

Molecular biology reports

|April 1, 2025

概括

菲塞丁是一种天然的黄类化合物,在保护对西斯普拉丁诱导的外围神经病变方面表现有前途. 这项研究证明了fisetin.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
毒理学毒理学毒理学

背景情况:

西斯普拉丁化疗经常导致外围神经病变,严重损害患者的生活质量.
自然的黄类化合物,如菲塞,具有抗氧化和抗炎性质,可能提供神经保护.

研究的目的:

为了研究fisetin在鼠模型中引起的外周神经病变中对fisetin的神经保护作用.
评估菲塞丁对外周神经系统的分子,结构和功能方面的影响.

主要方法:

雄性Wistar大鼠被给予西斯丁 (3毫克/公斤) 5周以诱导神经病变.
用费西丁 (10 mg/kg和 20 mg/kg) 来评估其治疗潜力.
评估包括行为测试,神经传导速度 (NCV) 测量,基因表达分析 (NF-kB,GPX4) 和坐骨神经结构评估.

主要成果:

西斯普拉丁诱导了运动和感觉缺陷,减少了NCV,髓损伤,增加了神经炎症 (NF-kB升高,GPX4降低).
菲塞丁治疗 (10毫克/公斤) 显著改善了运动协调,感官功能和NCV.
菲西通过增加GPX4和降低NF-kB来保持髓完整性,减少质激活,并通过增加GPX4和降低NF-kB恢复氧化/炎症平衡.

结论:

菲塞在老鼠中显示出显著的神经保护作用,可以预防西斯普拉丁诱导的外围神经病变.
菲西有助于恢复外周神经系统的分子,结构和功能完整性.
菲西显示出作为治疗药物的潜力,用于管理化疗诱导的神经病变.

关键词:

西斯普拉丁 (Cisplatin) 是一种鱼类素 (Fisetin) 是一种素.髓基蛋白是一种基础蛋白质.神经传导速度的神经传导速度.神经病变是一种神经病变.无感觉行为实验实验

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