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相关概念视频

Proteomics01:33

Proteomics

7.0K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.0K

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相关实验视频

Updated: May 8, 2025

TMT Sample Preparation for Proteomics Facility Submission and Subsequent Data Analysis
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使用SomaLogic平台的高吞吐量蛋白质组学

Hanjun Zhao1, Laura Winchester2

  • 1Department of Psychiatry, University of Oxford, Oxford, UK.

Methods in molecular biology (Clifton, N.J.)
|April 1, 2025
PubMed
概括
此摘要是机器生成的。

SomaLogic 的 SOMAscan 平台使用慢减速改性阿普塔默 (SOMAmer) 试剂提供高通量蛋白质测量. 这种蛋白质组学技术精确地量化了各种生物样本中的数千种蛋白质.

关键词:
亚普特美尔 (Aptamer) 是一种药物.不同表达式的差异表达式路径路径路径路径路径在Somalogic中使用Somalogic.

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples
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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

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相关实验视频

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Comprehensive Workflow of Mass Spectrometry-based Shotgun Proteomics of Tissue Samples

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科学领域:

  • 蛋白质组学和生物技术
  • 生物标志物发现和验证

背景情况:

  • 高通量蛋白质测量对于生物研究和诊断至关重要.
  • 现有的方法包括基于亲和力的测定和公正的质谱法.
  • SomaLogic的SOMAscan平台代表了一种基于亲和力的先进方法.

研究的目的:

  • 介绍和描述 SomaLogic 的 SOMAscan 平台用于蛋白质测量.
  • 突出SOMAscan平台在复杂化,灵敏度和吞吐量方面的功能.
  • 详细介绍使用SOMAmer试剂的基础技术.

主要方法:

  • 使用慢速修改型阿普塔默 (SOMAmer) 试剂进行蛋白质结合.
  • 采用高度多重化的测试方法,能够同时测量数千种蛋白质.
  • 适用于各种生物流体样本,包括CSF,血和血清.

主要成果:

  • 在SOMAscan平台上,可以进行精确,定量和可重复的蛋白质测量.
  • 实现高通量分析,快速测量蛋白质.
  • 展示了广泛的覆盖范围 (数千种蛋白质) 和深度量化 (高和低丰度蛋白质).

结论:

  • 该SOMAscan平台是一个尖端的蛋白质组学技术,用于全面的蛋白质分析.
  • 它的灵敏度,吞吐量和可重复性使其适合于各种生物应用.
  • 基于SOMAmer的体为促进蛋白质原子研究提供了一个强大的工具.