在冷解过程中, (H2) 对野猪精子的保护作用
1Institute of Animal Science and Veterinary Medicine, Shanghai Academy of Agricultural Sciences; Shanghai Engineering Research Center of Breeding Pig, Shanghai, China.
Cryo letters
|April 1, 2025
概括
补充气可以显著改善化解后的野猪精子质量. 这种抗氧化策略保护精子免受氧化应激,增强生命力和运动性,以获得更好的生殖结果.
科学领域:
- 生殖生物学 生殖生物学
- 冰冷保存科学 冰冷保存科学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 野猪精子在冷保存期间容易受到氧化应激.
- 抗氧化剂对于减轻精子中反应性氧物种 (ROS) 损伤至关重要.
- 冷解过程对精子的生存能力构成重大威胁.
研究的目的:
- 为了研究 (H2) 在冷解过程中对野猪精子的保护作用.
- 为了确定补充H2是否可以改善解后的精子质量和存活率.
- 评估H2对野猪精子中氧化应激标记物的影响.
主要方法:
- 将气添加到预稀释剂,冷扩展剂和解溶液中.
- 评估了精子活力,渐进性运动性,体完整性和线粒体活性.
- 测量了马隆迪甲 (MDA) 水平和总抗氧化能力 (T-AOC),以评估氧化应激.
主要成果:
- 补充剂显著提高了精子的活力,运动性,体完整性和线粒体活动.
- 在化后的野猪精子中,H2治疗导致T-AOC增加和MDA水平降低.
- 在所有三种溶液 (预稀释剂,冷扩展剂,解溶液) 中使用产生了最好的结果.
结论:
- 作为一种强大的抗氧化剂,在冷却和冷解过程中保护野猪精子免受ROS引起的损伤.
- 补充H2是一种有希望的策略,可以提高野猪精子冷保存的有效性.
- 这项研究强调了在保护辅助生殖技术的精子质量方面的潜力.
相关概念视频
Hydrogen Bonds
120.1K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
120.1K
Reduction of Alkenes: Catalytic Hydrogenation
11.7K
Alkenes undergo reduction by the addition of molecular hydrogen to give alkanes. Because the process generally occurs in the presence of a transition-metal catalyst, the reaction is called catalytic hydrogenation.
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
Metals like palladium, platinum, and nickel are commonly used in their solid forms — fine powder on an inert surface. As these catalysts remain insoluble in the reaction mixture, they are referred to as heterogeneous catalysts.
The hydrogenation process takes place on the...
11.7K
π Electron Effects on Chemical Shift: Overview
1.0K
An applied magnetic field causes loosely bound π-electrons in organic molecules to circulate, producing a local or induced diamagnetic field over a large spatial volume. As the molecules tumble in solution, the field generated by π-electrons in spherical substituents results in a zero net field. However, the net field generated by π-electrons in non-spherical substituents is not zero. The effect of this induced field depends on the orientation of the molecule with respect to B0,...
1.0K
Protection of Alcohols
7.2K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
7.2K
Protecting Groups for Aldehydes and Ketones: Introduction
6.5K
Protecting groups are compounds that can bind to a specific functional group in the presence of other functional groups to protect them from undesired chemical reactions. These compounds can selectively bind to particular functional groups and advance chemoselective reactions in polyfunctional systems (Figure 1). After the functional group has served its purpose, it is removed by reacting it with specific compounds.
6.5K
Peroxisomes
8.4K
Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...
8.4K


