临床干预研究中的顺序结果数据的元分析方法:用可重现的研究进行范围审查
Ali Mulhem1,2
1Westfälische Wilhelms-Universität Münster, Münster, Germany.
PloS one
|April 1, 2025
概括
对顺序结果数据的元分析是复杂的. 这次审查发现了最佳方法的知识差距,突出了对临床研究的顺序,二进制和连续模型的进一步研究的需要.
科学领域:
- 生物统计学 生物统计学
- 临床研究方法论 临床研究方法论
- 证据综合 证据综合
背景情况:
- 与二进制或连续数据相比,对顺序结果数据的元分析存在独特的挑战.
- 对于顺序结果的元分析方法的现有文献需要全面的总结和评估.
研究的目的:
- 系统地审查和总结当前生物医学文献的元分析方法的顺序结果.
- 试图复制以前关于顺序元分析方法的研究结果.
主要方法:
- 在MEDLINE,EMBASE和PsycINFO数据库中进行系统的文献搜索,并通过引用搜索来补充.
- 使用Covidence软件对333条记录进行选,包括两阶段选.
- 在临床干预研究中包括报告或比较顺序结果的元分析方法的研究;在数据允许的情况下,尝试进行可重复的研究.
主要成果:
- 四项方法研究符合纳入标准,重点是5-20类别的顺序尺度.
- 识别的方法包括顺序模型 (比例赔率,概括赔率),二元模型 (二分化) 和连续模型.
- 没有一项研究提供了全面的比较;可复制性尝试产生了差异,表明现有研究或解释中的潜在问题.
结论:
- 关于在临床环境中获得顺序结果的最佳元分析方法,仍然存在重大知识差距.
- 进一步的方法研究是必不可少的,以开发一个强大的证据基础来选择合适的元分析方法对顺序数据.
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