肺癌手术后手术后肺炎患者的肠道菌群的动态变化和代谢功能
Meiling Wang1,2, Weiting Jiang1, Tingyu Wei1
1Department of Healthcare-Associated Infection Management, The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
PloS one
|April 1, 2025
概括
肺癌患者的术后肺炎显示肠道细菌多样性和功能发生变化. 这种肠肺轴不平衡可能会增加感染风险,提供新的预防和治疗目标.
科学领域:
- 微生物组研究的研究.
- 肠肺轴 肠肺轴 肠肺轴
- 在瘤学瘤学.
背景情况:
- 手术后肺炎 (POP) 是肺癌手术后的常见并发症,影响患者的康复.
- 肠肺轴表明肠道菌群与肺部感染之间存在联系.
- 了解肠道微生物组的变化对于管理POP至关重要.
研究的目的:
- 研究患有POP的肺癌患者肠道菌群和代谢功能的动态变化.
- 确定POP预防和治疗的潜在目标.
主要方法:
- 将三个组进行比较:健康对照组,有POP的肺癌和没有POP的肺癌.
- 在手术前和感染后/术后收集的便样本.
- 使用了V3-V4区域的16S rRNA基因测序 (Illumina MiSeq).
主要成果:
- 与健康对照组相比,POP组显示阿尔法和明显的β多样性减少.
- 增加了埃格塞拉,科普罗巴西勒斯,佩普托斯特雷普托科克和细菌菌的丰富性 (致病性/机会性).
- 降低有益的布劳提亚的丰富性;改变了代谢途径 (增加了酸氨基醇信号传递,降低了某些氨基酸和酶的生物合成).
结论:
- 患有POP的肺癌患者表现出独特的肠道菌群特征.
- 减少微生物多样性和增加病原性细菌是POP的特征.
- 这些肠道微生物组的改变显著影响代谢功能,提供治疗见解.
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