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韩国癌症幸存者身体活动和死亡风险的变化:基于人口的队列研究
Thi Tra Bui1, Eunjung Park2, Hee-Yeon Kang1
1National Cancer Center, Goyang, Korea (South), Republic of.
概括
癌症诊断后增加体力活动显著降低了幸存者的死亡风险. 这种好处不管之前的活动水平如何,都会被观察到,这凸显了诊断后运动的重要性.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 癌症诊断后身体活动 (PA) 改变对生存结果的影响仍然不完全理解.
- 评估与PA从诊断前到诊断后的转变相关的死亡风险对于癌症幸存者护理至关重要.
研究的目的:
- 评估癌症诊断后身体活动水平变化与大量癌症幸存者的随后死亡风险之间的关联.
- 确定诊断后的身体活动是否会影响全因和癌症特异性死亡率.
主要方法:
- 一项基于人口的回顾性队列研究,利用韩国国家医疗保险服务数据库.
- 包括2009-2017年间诊断的215,191名癌症患者,在诊断前和诊断后评估了PA.
- 分析所有原因和癌症特异性死亡率,使用Cox比例危险回归,考虑PA变化.
主要成果:
- 诊断后开始体育活动的患者与始终不活动的患者相比,所有原因的死亡风险显著降低 (HR:男性,0.82;女性,0.87).
- 持续活跃的患者也经历了死亡率的降低 (HR:男性,0.77;女性,0.81),在PA和死亡率之间观察到剂量反应关系.
- 在各种癌症类型和癌症阶段,特别是在男性中,发现了PA和死亡率之间的反向关联.
结论:
- 诊断后的身体活动与癌症幸存者的全因死亡率以剂量依赖的方式降低有关.
- 身体活动对生存的积极影响是显而易见的,不管诊断前的活动水平如何.
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