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Updated: May 16, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Published on: July 25, 2013

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设计新型的默卡普托-3-烯烯二化物作为二重 ангиотензин转化酶C-域选择性/内普利辛抑制剂

Gyles E Cozier1, Lauren B Coulson2,3, Charles J Eyermann4

  • 1Department of Life Sciences, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

Journal of medicinal chemistry
|April 1, 2025
PubMed
概括

新的双重血管激素转化酶 (ACE) 和 neprilysin (NEP) 抑制剂被合成为选择性向cACE,改善高血压治疗,同时最大限度地减少副作用. 结构分析揭示了强大的双重抑制的关键特征.

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