药物状态是否会影响坚果在改变血压和脂质方面的有效性? 一个系统性审查和元分析
Hoi Y Wong1, Alison M Coates1, Sharayah Carter1,2
1Alliance for Research in Exercise, Nutrition and Activity (ARENA), Allied Health and Human Performance, University of South Australia, Adelaide, SA 5001, Australia.
Nutrition reviews
|April 1, 2025
概括
坚果的消费可以提高血脂,但不能提高血压. 对脂质的影响在不服用药物的患者中最大,尽管很少有研究分析药物使用情况.
科学领域:
- 心血管疾病的研究研究.
- 营养科学 营养科学
- 临床营养学 临床营养学
背景情况:
- 坚果的消费与更好的心血管疾病 (CVD) 风险因素,如血压 (BP) 和脂质失调有关.
- 目前尚不清楚血压和降脂药是否会影响这些益处.
研究的目的:
- 为了研究整个树果和花生如何影响血压和血脂.
- 为了确定血压和脂质的药物使用是否会改变这些效应.
主要方法:
- 在多个数据库 (MEDLINE,EMBASE,Scopus,Web of Science) 中系统搜索相关的随机对照试验 (RCT),直到2023年6月21日.
- 进行了随机效应元分析,根据参与者的药物状况 (药物,非药物,未报告,混合) 进行了子组分析.
- 包括115项研究,其中109项进行了元分析.
主要成果:
- 坚果消费显著降低了甘油三,总胆固醇,LDL胆固醇和其他脂质标记物,但没有影响HDL胆固醇或BP.
- 很少有研究只关注服用药物的参与者;混合组缺乏药物特定结果报告.
- 甘油三和阿波利波蛋白B在药物组之间显示出显著的差异,在未服用药物的个人中观察到的最大减少.
结论:
- 坚果的消费表明降脂的好处,但没有降血压的好处.
- 关于药物状态如何影响这些影响的数据有限.
- 需要进一步的研究来澄清坚果消费对接受药物治疗的心血管患者的益处.
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