小 (≤2厘米) 胃胃肠道 stromal 瘤的手术切除
1Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23, Back Road of Art Gallery, Dongcheng District, Beijing, 100010, China.
概括
手术切除为小胃肠道 stromal 瘤 (GIST) 提供了改善的整体生存率 ≤2厘米. 这项研究发现,手术管理显著有利于小GIST患者,尽管癌症特异性存活率没有显著差异.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 小胃胃肠道 stromal 瘤 (GIST) ≤2厘米,在手术切除方面存在治疗困境.
- 对于这些瘤的手术与非手术治疗的长期生存结果仍然不清楚.
研究的目的:
- 评估和比较小胃GIST (≤2厘米) 的手术和非手术治疗的长期生存结果.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库进行患者选择 (2000-2021).
- 员工倾向分数匹配 (PSM) 以尽量减少选择偏差.
- 应用卡普兰-梅尔分析和多变量考克斯模型来评估整体生存率 (OS) 和癌症特异性生存率 (CSS).
主要成果:
- 包括1229名患者:1004名 (81.69%) 进行手术,225名 (18.31%) 进行非手术.
- 在PSM后,操作管理显示了5年OS (82.79%对80.00%,P=0.039) 的显著改善.
- 运营管理与改善的操作系统有显著的关联 (HR=0.62,P=0.037),但不是CSS (HR=0.85,P=0.643).
结论:
- 经营管理在统计学上与小胃GIST (≤2厘米) 患者的整体存活率的改善有关.
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