鼻氧化作为慢性鼻炎治疗反应的客观评估工具
Sangeun Lee1, Su Mi Seong1, Hyeop Oh1
1Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea.
概括
鼻氧化 (nNO) 水平的变化与治疗后慢性鼻炎患者的症状改善相关. 这表明nNO可以作为评估上呼吸道炎症的客观工具.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 在慢性鼻炎中评估上呼吸道炎症是具有挑战性的,原因是影响鼻氧化 (nNO) 水平的解剖学变异和并发症.
- 这项研究研究了nNO变化的潜力,作为慢性鼻炎治疗疗效的可靠指标.
研究的目的:
- 评估鼻氧化 (nNO) 水平变化与治疗后慢性鼻炎患者的症状改善之间的相关性.
- 确定nNO是否可以作为评估慢性鼻炎治疗反应的客观指标.
主要方法:
- 一项前性观察性研究,涉及46名被诊断患有慢性鼻炎的参与者.
- 测量包括鼻氧化物 (nNO) 水平,症状得分 (鼻症状总得分 - TNSS,TNSS与眼部症状 - TNSS眼睛) 和生活质量 (犀牛结膜炎生活质量问卷 - RQLQ) 在基线和治疗1个月后.
- 基线实验室测试包括血清总IgE,血液中乙烯酸蛋白百分比和皮肤刺伤测试.
主要成果:
- 在治疗后观察到TNSS,TNSS眼睛和RQLQ得分的显著下降 (p<0.001).
- 在治疗后,鼻氧化 (nNO) 水平也显著下降 (p=0.036).
- nNO水平的变化与TNSS (p=0.047),TNSS眼睛 (p=0.021) 和RQLQ (p=0.004) 的改善有显著的相关性.
结论:
- 鼻氧化 (nNO) 水平的变化与慢性鼻炎患者治疗后的症状和生活质量改善有显著的相关性.
- 鼻氧化 (nNO) 显示出作为评估慢性鼻炎治疗有效性的客观工具的潜力,特别是在报告困难的患者中.
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