在各种流行病阶段的COVID-19中非严重的肝损伤:现实世界的研究
Jirayuth Winyupakorn1, Chunlanee Sangketchon2, Watcharaporn Devakul Na Ayutthaya3
1Division of Gastroenterology and Hepatology, Department of Medicine, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Dusit, Bangkok, 10300, Thailand.
概括
轻度COVID-19患者经历的肝损伤最小,允许在短期住院期间使用多种药物. 某些抗病毒药物,如法维皮拉维尔和雷梅西维尔,显示肝酶的暂时增加.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19的严重程度与肝脏损伤有关.
- 在轻度病例中,研究抗COVID-19药物对肝功能的影响至关重要.
研究的目的:
- 在入院后10天内,评估轻度至中度COVID-19患者的肝损伤动态.
- 为了确定肝损伤的危险因素,包括药物使用.
主要方法:
- 对300名轻度至中度COVID-19患者进行前性队列研究.
- 收集关于人口统计,治疗和肝损伤 (LI) 动态的数据.
- 评估了临床过程和药物对肝酶 (AST/ALT) 的影响.
主要成果:
- 在300名患者中,有115名患者出现肝损伤.
- 在正常基线水平的患者中,法维皮拉维尔,雷梅西维尔和法维皮拉维尔 + 艾弗梅克丁增加了AST / ALT水平.
- 地面玻璃成像与轻度LI相关;大多数患者在10天内显示过氨酶下降.
结论:
- 轻度至中度的COVID-19与有限的肝损伤有关.
- 临床医生可以安全地为这些患者在短期住院期间使用各种标准药物.
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