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结合FcRn对大脑中单克隆抗体配置的影响

Hsien Wei Huang1, Shengjia Wu1, Shufang Liu1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, 455 Pharmacy Building, Buffalo, New York, 14214-8033, USA.

The AAPS journal
|April 1, 2025
PubMed
概括

在中性和酸性pH值下增强与新生儿Fc受体 (FcRn) 结合的工程抗体显著增加了大脑暴露. 修改FcRn结合会影响抗体的大脑配置和保留.

关键词:
在FcRnnn中.结合性亲和力是一种结合性亲和力.大脑的药理动力学微透析是一种微透析.这是一种单克隆抗体.

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