随着时间的推移,骨质疏松症药物的使用在美国和加拿大
Kaleen N Hayes1,2,3, Andrew R Zullo4,5, Sarah D Berry6,7
1Department of Health Services, Policy, and Practice and Center for Gerontology and Healthcare Research, Brown University School of Public Health, 121 South Main Street, Providence, Rhode Island, USA. Kaley_hayes@brown.edu.
概括
美国和加拿大的骨质疏松症药物使用量仍然低于2008年的水平,药物选择有所不同. 德诺苏马布的使用正在增加,但整体启动尚未恢复,这需要进一步调查查和治疗不足.
科学领域:
- 药理学和老年医学 药理学和老年医学
- 公共卫生和流行病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 由于安全问题,骨质疏松症药物的使用在2008-2012年间在全球范围内下降.
- 骨质疏松症药物启动和使用的最新趋势尚未得到充分描述.
- 了解当前的处方模式对于管理老年人群中的骨质疏松症至关重要.
研究的目的:
- 描述和比较骨质疏松症药物的启动和整体使用的时间趋势.
- 分析美国 (US) 和加拿大安大略省 (ON) 的老年人中的这些趋势.
主要方法:
- 一个连续的横截面研究,利用医疗保健行政数据 (ON) 和医疗保险索赔数据 (US).
- 包括在社区居住的66岁以上的老年人开始服用骨质疏松症药物.
- 数据分析涵盖了1996-2022年 (英国) 和2008-2020年 (美国) 的时间段.
主要成果:
- 在2008年至2011年期间,美国的骨质疏松症药物开始显著下降 (58%),而不是在英国 (29%).
- 在这两个国家,整体开始使用骨质疏松症药物并没有恢复到2008年以前的水平.
- 德诺苏马布的使用在美国和澳大利亚都在增加,尽管常见的初始疗法不同 (美国的阿伦德罗纳特,澳大利亚的瑞塞德罗纳特).
结论:
- 新型骨质疏松症药物使用量仍低于2008年之前的水平,并且在美国和加拿大之间呈现出明显的模式.
- 需要进一步的研究来确定这些趋势的驱动因素,包括查策略和持续的安全问题.
- 了解这些因素对于优化骨质疏松症治疗和患者结果至关重要.
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