对患有上升性大动脉扩张患者的血清蛋白质学分析
Kun Liu1,2, Yuchen Wang1, Zhidong Ye3
1Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cardiovascular toxicology
|April 1, 2025
概括
血清蛋白质学为上升大动脉扩张 (AAD) 和胸部上升大动脉剖析 (TAAD) 确定了新的生物标志物. NUP188显示出作为AAD诊断生物标志物的潜力,有助于早期发现疾病.
科学领域:
- 心血管研究研究心血管研究
- 蛋白质组学是指蛋白质组学.
- 生物标志物发现发现
背景情况:
- 上升大动脉扩张 (AAD) 是危及生命的急性大动脉综合征的关键风险因素.
- 由于AAD的无症状性质,早期诊断具有挑战性.
- 血清诊断生物标志物对于疾病鉴定至关重要.
研究的目的:
- 使用蛋白质学识别血清蛋白质生物标志物用于上升大动脉扩张 (AAD) 和胸部上升大动脉剖析 (TAAD).
- 为了比较AAD,TAAD和健康对照之间的蛋白质表达特征.
- 评估已识别的蛋白质的诊断潜力.
主要方法:
- 在AAD患者,TAAD患者和健康对照的血清样本上使用了无标签的定量蛋白质组学.
- 使用基因本体学 (GO) 和KEGG数据库识别和功能分析了差异丰富的蛋白质 (DAP).
- 使用接收器操作特征 (ROC) 曲线分析来评估诊断潜力.
主要成果:
- 与对照人群相比,蛋白质组分析显示AAD中有40个DAP,TAAD中有52个DAP.
- 在AAD中DAP与抗菌反应和炎症有关;TAADDAP与染色质调节和细胞分化有关.
- 在AAD和TAAD之间观察到蛋白质表达的显著重叠.
- 在AAD中,NUP188被显著下调,并通过ROC分析证明了其作为诊断生物标志物的潜力.
结论:
- 蛋白质组学是发现大动脉疾病中的血清生物标志物的强大工具.
- 独特的蛋白质表达特征标志着AAD和TAAD,具有重叠的特征.
- NUP188是一种有前途的候选生物标志物,用于早期诊断上升大动脉扩张.
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