在美国怀孕期间的SARS-CoV-2后长期COVID
Chengxi Zang1, Daniel Guth2, Ann M Bruno3
1Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA. chz4001@med.cornell.edu.
Nature communications
|April 1, 2025
概括
怀孕可能会改变COVID-19的结果,但孕妇的长期COVID风险低于非孕妇. 危险因素包括种族,年龄,三个月,肥胖和并发症.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 生殖健康 生殖健康
背景情况:
- 怀孕调节免疫反应和COVID-19的严重程度.
- 怀孕对长期COVID发展的影响还不清楚.
- 了解怀孕期间的长期COVID对于母婴健康至关重要.
研究的目的:
- 为了比较孕妇和非孕妇感染SARS-CoV-2的长期COVID发病率.
- 在孕妇人群中识别与长期COVID相关的风险因素.
主要方法:
- 美国两大数据库的回顾性分析:PCORnet和N3C.
- 包括怀孕个体 (18-50岁) 和匹配的非怀孕对照与SARS-CoV-2感染.
- 在感染后180天使用计算表型模型进行长COVID评估.
主要成果:
- 估计的长期COVID发病率在数据库之间有所不同 (PCORnet中的16.47/100,N3C中的4.37/100).
- 与非孕妇相比,孕妇的长期COVID调整危险比率较低 (PCORnet: 0.86,N3C: 0.70).
- 长期COVID的危险因素包括黑人种族/种族,晚期孕产妇年龄,第一/第二季度感染,肥胖和并发性疾病.
结论:
- 虽然长期COVID是孕妇的一个重大问题,但他们的风险似乎低于匹配的非孕妇人群.
- 特定的人口和临床因素增加了怀孕期间长期COVID的风险.
- 需要进一步的研究来阐明这些观察到的差异背后的机制.
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