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Updated: May 16, 2025

Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices
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Two-photon Calcium Imaging in Neuronal Dendrites in Brain Slices

Published on: March 15, 2018

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对PPEF酸酶家族的双 Ca2+传感器介导激活的结构洞察

Jia Liu1, Cang Wu2,3, Yuyang Liu1

  • 1Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong, China.

Nature communications
|April 1, 2025
PubMed
概括

有EF手的血清蛋白/氨酸蛋白酸酶 (PPEF) 使用离子 (Ca2+) 调节其活性. 这项研究揭示了与卡尔莫杜林结合的Ca2+如何通过解锁催化位点来激活PPEF,从而提供治疗潜力.

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