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饮食因素和端粒长度之间的因果关系由门德尔随机化揭示
Xinghai Yue1, Hongfei Liu1, Wenzhao Guo1
1Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Scientific reports
|April 1, 2025
概括
干燥水果的摄入可能会导致端粒长度增加,这是衰老的标志. 这项门德尔随机化研究表明,干果可能是健康老龄化和疾病预防的饮食策略.
科学领域:
- 遗传学 是一个遗传学.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 观察性研究表明饮食和端粒长度之间存在联系,但受到混和反向因果关系的限制.
- 端粒长度是细胞衰老的生物标志物,与各种与年龄相关的疾病有关.
- 门德尔随机化 (MR) 提供了一个强大的方法,通过利用遗传变异作为工具变量来推断因果关系.
研究的目的:
- 调查各种饮食因素与端粒长度之间的潜在因果关系.
- 为了最大限度地减少观察性研究中固有的偏差,使用两样本的门德尔随机化设计.
主要方法:
- 利用IEU开放GWAS项目进行暴露 (20种饮食因素) 和结果 (端粒长度) 数据.
- 进行了两个样本的门德尔随机化分析,使用MRPRESSO和辐射MR检测异常值.
- 进行了异质性,质性,多变量门德尔随机化 (MVMR) 和MR-lap分析以确定稳定性和灵敏性.
主要成果:
- 在干果摄入量和端粒长度 (P=9.089×10^-4) 之间发现了显著的积极因果关系.
- 在去除异常值 (P=7.323×10^-5) 和灵敏度分析后,这种关联仍然显著.
- 没有检测到任何显著的性变异,MVMR/MR-lap分析支持因果关系;其他饮食因素需要进一步调查.
结论:
- 研究结果表明,干果消费在促进长端粒长度方面可能起到潜在的因果作用.
- 这突出了干果作为健康衰老策略的潜在饮食成分.
- 需要进一步的研究来证实其他饮食因素对端粒长度的影响.
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