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Updated: May 16, 2025

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
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Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane

Published on: March 30, 2015

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内体化物/质子交换器需要抑制性TMEM9β子单元来调节和预防引起疾病的过度活动

Rosa Planells-Cases1, Viktoriia Vorobeva1,2, Sumanta Kar1

  • 1Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.

Nature communications
|April 1, 2025
PubMed
概括

TMEM9和TMEM9B蛋白对于内体化物/质子交换器 (CLC) 是必不可少的. 这些蛋白调节CLC的贩运,并抑制它们的离子运输,防止内体胀和疾病.

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

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