在2型糖尿病中COVID-19和神经病变
Georgios Ponirakis1, Ibrahim Al-Janahi2, Einas Elgassim1
1Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
在2型糖尿病患者中,COVID-19并没有使糖尿病外围神经病变恶化. 然而,低血压,脂质升高和女性性别等因素与长期COVID症状的发展有关.
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 糖尿病周围神经病变 (DPN) 是2型糖尿病 (T2D) 的常见并发症.
- 在T2D患者中,COVID-19对DPN的影响尚不清楚.
- 调查COVID-19及其T2D后续的危险因素至关重要.
研究的目的:
- 在T2D患者中确定COVID-19的危险因素.
- 评估COVID-19对DPN的发展和进展的影响.
- 在这个人群中确定严重COVID-19和长期COVID的预测因素.
主要方法:
- 76名T2D患者的前性研究.
- 评估包括NICE后COVID问卷,DN4,振动感知值 (VPT) 和角膜共聚焦显微镜 (CCM).
- 在COVID-19之前和随访期间收集的数据 (COVID-19后11.0±8.9个月).
主要成果:
- 35%的患者患有COVID-19,其中22.9%的患者患有严重COVID,25.7%患有长期COVID.
- COVID-19 的发展与较低的缩血压有关.
- 在DPN和COVID-19,严重COVID-19或长期COVID之间没有发现任何关联.
- 女性更有可能患上长期COVID;体重升高,LDL和VPT也与此相关.
- 长期COVID组显示了甘油三,LDL和体重的显著变化.
- 在COVID-19和非COVID-19组中,角膜神经的测量显著减少.
结论:
- 在T2D患者中,COVID-19似乎不会影响DPN的发展或进展.
- 低缩血压,脂质变化,体重,较高的VPT和性别可能会影响T2D中的COVID-19结果.
- 需要进一步的研究来了解COVID-19对T2D并发症的长期影响.
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