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尿中诺米他内,是上腺腺瘤患者死亡风险的预测因子
Albin Kjellbom1,2, Magnus Löndahl3, Malin Danielsson3,4
1Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. albin.kjellbom@med.lu.se.
尿中诺美甲尼水平预测了上腺腺瘤患者的死亡率. 这一发现建议使用这种常见的测试来更好地评估患者的风险.
科学领域:
- 内分泌学 在内分泌学.
- 临床诊断 临床诊断 临床诊断
- 流行病学 流行病学
背景情况:
- 尿中甲基尼是用于染细胞瘤查的标准.
- 它们在上腺腺瘤死亡风险中的作用尚未研究.
研究的目的:
- 在上腺腺瘤患者中研究尿中甲基内弗林作为死亡率标志物.
- 评估尿中诺米他内和甲基他内的预后价值.
主要方法:
- 对879名患有上腺腺瘤的成年患者进行了回顾性队列研究 (2005-2022年).
- 在纳入时对24小时尿液 (tU) 中甲氨酸和甲氨酸水平的分析.
- 从国家死亡原因登记处获得的全因死亡率数据.
主要成果:
- 增加的tU-normetanephrine与更高的死亡率相关 (aHR 1.47).
- 没有发现tU-甲基内和死亡率 (aHR 0.96) 之间有显著的关联.
- 在平均9.9年的随访期间,发生了278例死亡.
结论:
- 尿中诺美甲尼是上腺腺瘤患者死亡的潜在预测因子.
- 这种诊断测试可以帮助这些患者的风险分层.
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