在aflibercept 8 mg和aflibercept 2 mg后的早期眼内压力动态:倾向性得分匹配分析
Valentina Sarao1,2, Daniele Veritti1, Francesco Bonini1
1Department of Medicine-Ophthalmology, University of Udine, Udine, Italy.
Eye (London, England)
|April 1, 2025
概括
在患有AMD或DMO的患者中,内阿弗利塞普特8mg和2mg显示出类似的眼内压力 (IOP) 动态. IOP尖峰在30分钟内迅速正常化,这表明对玻璃眼或DMO患者进行仔细监测.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 内阿弗利塞普特是新血管与年龄相关的黄斑变性 (AMD) 和糖尿病黄斑 (DMO) 的关键治疗方法.
- 了解不同阿弗利塞普特剂量 (8毫克与2毫克) 对眼内压力 (IOP) 的影响,对于患者的安全和管理至关重要.
- 之前的研究表明,在静脉内注射后,内血压的潜在波动,需要进一步调查早期动态.
研究的目的:
- 为了比较早期眼内压力 (IOP) 动态,在注射了aflibercept 8 mg和aflibercept 2 mg后进行了视内注射.
- 使用倾向得分匹配分析与其他眼睛对照来确保可靠的比较.
- 为了确定显著的内血压升高的预测因子,在静脉直通的aflibercept管理后.
主要方法:
- 一项前性观察性研究,涉及未经治疗的患有新血管性AMD或DMO的患者.
- 在注射后的多个时间点 (基线,1分钟,10分钟,30分钟和3个月) 使用iCare反弹度计测量眼内压力 (IOP).
- 使用倾向分数匹配,未经治疗的同眼作为对照.
主要成果:
- 无论是8毫克和2毫克的阿弗利伯塞特都诱导了显著的立即IOP升高 (p < 0.001),该升高在注射后30分钟正常化.
- 在8毫克和2毫克配方之间没有观察到IOP动态的显著差异 (p > 0.05).
- 预先存在的玻璃眼瘤是持续内血压升高的最强预测因素,DMO眼睛与新血管AMD眼睛相比,初始内血压峰值更高.
结论:
- 静脉膜内阿弗利伯塞普8毫克呈现出与2毫克配方相比的IOP动态.
- 内血压尖峰的快速正常化发生在静脉直肠注射aflibercept注射后30分钟.
- 加强IOP监测可能对接受aflibercept治疗的青光眼或DMO患者有益.
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