减少干预研究在设计和进行过程中的偏差风险:范围审查
Zhilin Ren1, Angela Claire Webster1, Kylie Elizabeth Hunter1
1NHMRC Clinical Trials Centre, University of Sydney, Locked Bag 77, Camperdown, Sydney, NSW, 1450, Australia.
BMC medical research methodology
|April 1, 2025
概括
很少有干预措施可以减少干预研究中的偏见. 这次审查发现,教育,独立委员会和参与者激励措施可以在研究设计和进行过程中减轻偏见.
科学领域:
- 临床研究方法论临床研究方法论
- 基于证据的医学是基于证据的医学.
- 生物统计学 生物统计学
背景情况:
- 干预性研究对于强有力的证据至关重要,但容易产生偏见.
- 偏差风险评估已经取得了进展,但在研究设计和进行期间的干预措施仍然不清楚.
研究的目的:
- 确定减少或预测干预研究中偏差风险的干预措施.
- 在研究设计和进行过程中评估这些干预措施的有效性.
主要方法:
- 对文献数据库和灰色文献进行了全面的范围审查.
- 自然语言处理补充了对相关出版物的搜索.
- 包括的研究描述了在研究设计或进行期间实施的干预措施,以减少偏见.
主要成果:
- 只有三项研究符合纳入标准,确定了三个不同的干预措施.
- 干预措施1:对研究人员进行严格的参与者查和跟踪的教育和培训.
- 干预措施2:独立的临床事件委员会,以减轻利益冲突.
- 干预措施3:为随机对照试验的参与者提供经济激励.
结论:
- 尽管存在偏见的显著影响,但经验干预很少.
- 教育,独立监督和参与者激励措施在缓解偏见方面表现有前途.
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