抗结核治疗后肠道微生物组的变化:来自中国东部的前性队列
Simin Zhang1,2, Zhipeng Xu3, Zhan Wang1
1Department of Epidemiology, Key Laboratory of Public Health Safety and Emergency Prevention and Control Technology of Higher Education Institutions in Jiangsu Province, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, PR China.
BMC infectious diseases
|April 1, 2025
概括
结核病治疗显著减少了肠道微生物群的多样性,特别是在密集治疗期间. 虽然肠道微生物群在治疗后显示部分恢复,但这个过程非常缓慢.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 结核病的治疗需要长时间使用抗生素 (≥6个月).
- 长期使用抗生素可以破坏肠道微生物群,可能会影响结核病的进展.
- 结核病治疗期间肠道微生物群的变化存在有限的研究.
研究的目的:
- 调查肠道微生物群组成和结核病治疗阶段之间的关系.
- 分析抗结核治疗期间在不同时间点发生的肠道微生物群变化.
主要方法:
- 多中心,观察性前性队列研究.
- 胃肠道症状评分尺度用于不适的评估.
- 在基线,2个月和6个月收集的便样本用于DNA测序和多样性分析.
主要成果:
- 85名参与者提供了完整的便样本;平均年龄为41.8岁.
- 抗结核治疗显著减少了肠道微生物群的多样性.
- 在2个月后观察到α多样性的短暂下降,在6个月后缓慢的部分恢复.
结论:
- 抗结核治疗对肠道微生物群和胃肠道功能产生了深远的影响.
- 强化治疗后,肠道微生物群显示部分恢复,但这是一个非常缓慢的过程.
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