血清炎作为儿童系统性红血性狼预后不佳的指标
Wei-Chen Kao1,2, Ya-Chiao Hu1, Jyh-Hong Lee1
1Department of Pediatrics, National Taiwan University Children's Hospital, No. 7, Zhongshan S. Road, Zhongzheng District, Taipei City, 100, Taiwan.
Pediatric rheumatology online journal
|April 1, 2025
概括
患有血清炎的儿童性狼患者面临更高的疾病活性和死亡率. 血清炎,特别是晚期发病的血清炎,加上末期病,显著增加了长期生存风险.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 自免疫性疾病 自免疫性疾病
- 临床结果研究研究
背景情况:
- 系统性红斑狼 (SLE) 是一种复杂的自身免疫性疾病,影响多个器官系统.
- 血清炎,或血清炎的炎症,是SLE的常见表现.
- 了解儿童发病SLE (cSLE) 中的血清炎对于预测患者的长期结果至关重要.
研究的目的:
- 为了研究患有SLE的儿科患者血清炎的临床特征.
- 分析cSLE中血清炎和长期存活率之间的关联.
- 为了确定患有血清炎的cSLE患者的死亡风险因素.
主要方法:
- 对于在2002年至2022年期间被诊断为cSLE患者的医疗记录的回顾性审查.
- 对血清炎的临床特征的分析 (多发性肺炎/带出血的心膜炎).
- 考克斯比例危险回归和卡普兰-梅尔生存分析以评估死亡风险.
主要成果:
- 185名cSLE患者中有20.54%患有血清炎.
- 血清炎与较年轻的诊断年龄,较高的疾病活性以及狼性炎,中枢神经系统问题和末期病 (ESRD) 的患病率增加有关.
- 血清炎 (HR:5.585) 和ESRD (HR:13.956) 独立预测死亡率;联合血清炎和ESRD显示最差的生存率.
结论:
- 患有狼血清炎的儿童表现出更大的疾病活性,更多的并发症和更高的死亡率.
- 晚期发病的血清炎,特别是与ESRD同时发生时,显著增加了cSLE中长期存活率低下的风险.
- 早期发现和治疗血清炎和ESRD对于改善儿科狼患者的治疗结果至关重要.
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