在中国与临床抗菌素耐药性相关的因素:全国性的分析
Wenyong Zhou1,2, Zexuan Wen1,2, Wenlong Zhu3
1Shanghai Institute of Infectious Disease and Biosecurity, School of Public Health, Fudan University, Shanghai, 200032, China.
Infectious diseases of poverty
|April 1, 2025
概括
中国的抗菌素耐药性 (AMR) 与抗生素使用和空气污染,特别是PM2.5.5有关. 解决这些因素的综合战略对于未来的抗菌药物耐药性控制至关重要.
科学领域:
- 环境科学 环境科学
- 公共卫生 公共卫生
- 微生物学 微生物学
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球健康挑战.
- 了解AMR的多面驱动因素对于有效的控制策略至关重要.
- "一个健康"的方法对于分析影响AMR的相互关联因素至关重要.
研究的目的:
- 研究人类和兽医抗生素使用,环境,社会经济和医疗保健因素以及中国的临床抗菌素耐药性之间的关联.
- 评估各种因素对抗药性耐药性流行病的贡献.
- 通过不同的干预措施来估计抗菌素耐药性的潜在降低.
主要方法:
- 来自中国抗菌素耐药性监测系统 (2014-2022) 的20762383个细菌分离物的分析.
- 利用回归模型来探索AMR与多个独立变量之间的关系.
- 根据2019年六种不同的措施估计了AMR的可避免风险.
主要成果:
- 抗菌素耐药性与人类和兽医抗生素使用,PM2.5水平,人口密度,人均GDP和住院时间正相关.
- 抗菌药物耐药性与水的受欢迎程度,人均绿化面积和人均卫生支出有负相关性.
- 确定PM2.5是主要因素,导致AMR变化的13.7%,并与显著的过早死亡和经济损失有关.
结论:
- 中国的抗菌药物耐药性是复杂的,受到PM2.5.5等相互关联因素的影响.
- 虽然在降低AMR方面取得了一些进展,但综合战略是必要的.
- 未来的举措必须同时针对PM2.5和其他驱动因素,以有效减少AMR.
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