回到绘图板:探索创伤性血胸部的组成和物理特性
Nathaniel McLauchlan1, Irina N Chernysh, Kandace Gollomp
1From the Perelman School of Medicine (N.M.), and Department of Cell and Developmental Biology (I.N.C., J.W.W.), Perelman School of Medicine, University of Pennsylvania; Department of Pediatrics (K.G.), Division of Hematology, Children's Hospital of Philadelphia; Department of Surgery (A.B.A.), Hospital University of Pennsylvania; Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery (L.F., J.W.C.), and Penn Acute Research Collaboration, Department of Surgery (S.M., J.W.C.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and Department of Surgery (J.W.C.), Uniformed Services University of the Health Sciences, Bethesda, Maryland.
创伤性血胸 (HTX) 凝块随着时间的推移在身体上发生变化,在72小时后变得更强大和更收缩. 了解HTX血栓组合中的这些变化可以指导更好的治疗策略.
科学领域:
- 胸部外科手术 胸部外科手术
- 创伤管理 创伤管理
- 生物材料科学 生物材料科学
背景情况:
- 创伤性血胸 (HTX) 管理通常需要由于持续的凝块负担而进行二次干预.
- 研究HTX血栓的物理特性和组成对于优化治疗策略至关重要.
- 假设:HTX血栓的组成和物理特性因受伤后的时间不同而有所不同.
研究的目的:
- 为了描述血胸血栓随着时间的推移而发生的物理特性和组成的变化.
- 为了将这些变化与受伤的时间和潜在的治疗影响相关联.
主要方法:
- 在外科手术过程中采集血胸样本.
- 样本被分为急性 (<72小时) 或亚急性 (≥72小时) 伤害后.
- 风力测量测量了压力强度;扫描电子显微镜分析了组成和收缩.
主要成果:
- 亚急性血栓 (≥72小时) 的压力强度明显高于急性血栓 (<72小时).
- 急性血栓中含有更高比例的双红细胞,并且收缩较少.
- 在急性和亚急性血栓之间,形红细胞或纤维素的比例没有显著差异.
结论:
- 血胸血栓的物理特性和组成随着时间的推移而发生显著变化.
- 早期干预机械辅助,如胸腔洗,可能对急性HTX有益.
- 合同,不那么多孔的亚急性血栓表明,当与破坏性方法相结合时,Lytic疗法的有效性得到提高.
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