遗传和环境对牙弧形特征发展的贡献:一个纵向双胞胎研究
Jamal Giri1, Michelle Bockmann1, Alan Brook1
1Adelaide Dental School, Faculty of Health and Medical Sciences, The University of Adelaide, 1 Frome Road, Adelaide, SA 5000, Australia.
European journal of orthodontics
|April 2, 2025
概括
遗传和环境因素在整个发育过程中显著影响牙弧形特征. 虽然大多数特征都表现出基因和环境影响的波动,但门长度和牙间宽度表现出从初级到永久牙的高度遗传性.
科学领域:
- 人类遗传学 人类遗传学
- 矯正牙科 矯正牙科是一種矯正牙科.
- 发展生物学 发展生物学
背景情况:
- 了解牙弧变化的病因对于正牙诊断和治疗规划至关重要.
- 双胞胎研究对于剖析遗传和环境因素对复杂表型的贡献是有价值的.
研究的目的:
- 量化添加基因 (A),共享环境 (C) 和非共享环境 (E) 因素对牙弧形特征的表型变异的相对贡献.
- 检查这些遗传和环境影响如何在初级,混合和永久牙阶段发生变化.
主要方法:
- 利用来自188个澳大利亚双胞胎对 (单胞胎和双胞胎) 的数字牙科模型.
- 测量了关键的牙弧度参数,包括牙间宽度,牙间宽度,弧度长度,过射和过咬.
- 应用遗传结构方程建模来分析双胞胎数据并估计遗传性和环境影响.
主要成果:
- 添加基因 (A) 和非共享环境 (E) 模型最好地解释了大多数牙弧形特征变异.
- 观测到高遗传性 (0.65-0.88) 的内弓特征,而内弓特征显示低到中等的遗传性 (0.21-0.51).
- 牙长度和牙间宽度在牙发育阶段表现出一致的高遗传性 (>0.8);初级牙发育中的超射受共享 (C) 和非共享 (E) 环境因素的影响.
结论:
- 牙弧的发育主要是由附加的遗传因素和非共享的环境影响所塑造的.
- 遗传和环境对大多数牙弧形特征的贡献在发育过程中波动,在混合牙阶段遗传影响显著下降.
- 牙长度和牙间宽度代表了在整个牙发育过程中具有强大,稳定的遗传决定的特征.
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