Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Organization01:24

Protein Organization

6.0K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.0K
Protein-protein Interfaces02:04

Protein-protein Interfaces

12.4K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.4K
Mechanical Protein Functions01:58

Mechanical Protein Functions

4.9K
Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
4.9K
Protein Networks02:26

Protein Networks

3.9K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
3.9K
Protein Folding01:25

Protein Folding

7.6K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
7.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Acupoint electrical stimulation with implantable carbon nanotube electrodes mitigates sciatic nerve injury-induced muscle atrophy.

Biomedical materials (Bristol, England)·2026
Same author

Carbon nanotube fiber electrode-based implantable electroacupuncture ameliorates myocardial ischemia in rats via the FXR/SHP pathway.

Nanotechnology·2026
Same author

EnzymeMiner 2.0: advancing automated enzyme discovery with expansive sequence mining and smart property analysis.

Nucleic acids research·2026
Same author

Tissue clock-guided prediction and intervention of futile recanalization: towards precision therapy in mechanical thrombectomy.

Frontiers in neurology·2026
Same author

Molecular PET imaging of tumor-associated macrophages in precision oncology.

Cancer letters·2026
Same author

Stepwise engineering of AmpR-based whole-cell biosensors for broad-spectrum detection and high-throughput screening of β-lactam compounds.

Biosensors & bioelectronics·2026

相关实验视频

Updated: May 16, 2025

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

300

[人工智能增强的基于物理的蛋白质计算建模技术]

Baoyan Liu1, Shuai Li1,2, Hao Su1,2

  • 1State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
|April 2, 2025
PubMed
概括
此摘要是机器生成的。

人工智能 (AI) 增强了基于物理的蛋白质计算建模. 这种方法提高了生物制造的效率和准确性,为生物挑战提供了新的解决方案.

关键词:
人工智能的人工智能是人工智能.计算生物学是计算生物学.计算建模计算建模分子对接的分子对接.分子动力学模拟模拟量子化学计算的计算方法

更多相关视频

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.4K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K

相关实验视频

Last Updated: May 16, 2025

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
05:57

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function

Published on: April 26, 2024

300
A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.4K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K

科学领域:

  • 生物技术和生物制造
  • 计算生物学 计算生物学
  • 蛋白质科学 蛋白质科学

背景情况:

  • 计算建模对于理解生物系统和指导实验至关重要.
  • 传统的基于物理的蛋白质建模方法在平衡准确性和速度方面面临挑战.
  • 生物数据的增长使得先进的人工智能 (AI) 模型的开发成为可能.

研究的目的:

  • 探索人工智能与基于物理的蛋白质计算建模方法的整合.
  • 在计算效率和准确性方面解决传统建模技术的局限性.
  • 突出AI增强模型在生物制造应用中的潜力.

主要方法:

  • 开发和应用AI增强的基于物理的计算建模技术.
  • 利用大型生物数据集进行AI模型培训和验证.
  • 将既定的物理原理与人工智能的数据处理和模式识别能力相结合.

主要成果:

  • 人工智能增强的建模显著提高了计算效率和预测准确度.
  • 综合方法提供了增强的解释能力,可转移性和稳定性.
  • 在生物催化剂应用中证明了潜力和价值.

结论:

  • 人工智能增强的基于物理的计算建模代表了蛋白质建模的重大进展.
  • 这一综合战略为生物制造研发提供了一个强大的新方向.
  • 它为解决复杂的生物挑战的新技术解决方案铺平了道路.