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Updated: May 16, 2025

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation
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[半尺度模拟和生物过程的AI优化]

Zhihui Wang1, Cong Wang2, Qinghua Zhang1,3

  • 1State Key Laboratory of Petroleum Molecular & Process Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology
|April 2, 2025
PubMed
概括

生物工艺对于可持续的生物制造至关重要,但优化起来很复杂. 中等尺度模拟和人工智能 (AI) 集成为理解和增强这些过程提供了强大的工具.

关键词:
人工智能 (AI) 的优化优化生物过程生物过程.计算流体动力学的流体动力学.机器学习是机器学习.在中尺度模拟中进行模拟.

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Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
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