早期和长期的甲状腺功能障碍在患者的头部和部状细胞癌在外部放射治疗后:临床病理学风险因素
Adriana Russo Fiore1, Gustavo Jacob Lourenço2, Eduardo Baldon Pereira3
1Department of Internal Medicine, School of Medical Sciences, Endocrinology Division, University of Campinas, São Paulo, Brazil.
Head & neck
|April 2, 2025
概括
在头癌放射治疗后,甲状腺功能障碍很常见. 早期和定期的甲状腺功能监测至关重要,特别是对于糖尿病或晚期癌症患者.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
背景情况:
- 接受放射治疗 (RT) 的头角状细胞癌 (HNSCC) 患者有甲状腺功能障碍 (TD) 的风险.
- 在这个人群中评估TD的发病率和特征对于患者管理至关重要.
研究的目的:
- 评估HNSCC患者治疗外部RT的早期和长期甲状腺功能障碍的患病率和模式.
- 识别与RT后的TD发展相关的风险因素.
主要方法:
- 分析了285名接受RT (单独或与其他疗法结合) 的HNSCC患者队列.
- 监测甲状腺功能,以检测RT的早期和长期影响.
主要成果:
- 在随访期间,54.7%的患者观察到甲状腺功能障碍,53.7%的患者经历了长期的TD.
- 亚临床甲状腺功能低下是最常见的诊断 (43.5%),特定的TSH水平与TD风险相关.
- 二型糖尿病,转移性淋巴结和缺少瘤切除被确定为TD风险因素.
结论:
- 频繁的甲状腺功能监测是必要的HNSCC患者后RT.
- 建议特别警2型糖尿病患者,淋巴结参与,或没有接受手术切除瘤的患者.
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