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在犬乳腺瘤中粉样沉积物的表征

Yuka Kato¹, Natsumi Kobayashi¹, Susumu Iwaide¹

¹Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

|April 2, 2025

概括

粉样蛋白沉积发生在35%的狗乳腺体中,与瘤等级和衰老有关. 这表明乳腺蛋白质稳定性障碍有助于狗的粉样蛋白形成.

科学领域:

兽医病理学兽医病理学
狗类瘤学狗类瘤学
生物化学生物化学

背景情况:

狗的乳腺瘤相关的氨基粉症尚未得到研究.
之前的研究缺乏关于发病率和易感因素的数据.

研究的目的:

确定粉样蛋白沉积在狗乳腺群体中的患病率.
调查病因因素,包括瘤等级和年龄.

主要方法:

对183只狗的252个乳腺质量的组织学检查.
粉样蛋白沉积模式的分类 (风,粉体,光分泌物).
免疫组织化学和质谱学用于蛋白质识别.

主要成果:

在乳腺体质量的35% (88/252) 中发现了氨基酸沉积物.
瘤内部的 stromal 沉积与较高的瘤等级 (II 和 III) 相相关.
瘤外粉样蛋白沉积与患者年龄的增加有关.

结论:

狗乳腺中粉样蛋白的形成与瘤发生和衰老有关.
蛋白质静止的破坏在粉样性粉症的发展中起作用.
确定了特定的粉样蛋白类型 (血清粉样蛋白A,α-S1-素).

关键词:

氨基化物氨基化物狗乳腺瘤狗乳腺瘤咖啡因中的咖啡因.血清中的粉样蛋白A.

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