登德罗帕纳克斯 (Dendropanax morbiferus) 对认知功能和大脑皮层厚度的影响:一个随机,双盲,安慰剂控制的随机试验
Chaewon Suh1, Shinhye Kim2, Yoonji Joo1
1Ewha Brain Institute, Ewha Womans University, Seoul, Republic of Korea.
Journal of Alzheimer's disease : JAD
|April 2, 2025
概括
丹德罗帕纳克斯 (Dendropanax morbiferus) 叶片提取物显著改善了主观认知衰退 (SCD) 患者的注意力,记忆力和全球认知功能. 这种天然化合物还增加了皮质厚度,这表明早期阿尔茨海默病干预的潜力.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 对主观认知衰退 (SCD) 的早期干预对于预防阿尔茨海默病 (AD) 进展至关重要.
- 在动物模型中,Dendropanax morbiferus (DM) 是有前途的,但它对人类认知能力下降的影响需要进行调查.
- 评估DM在SCD患者中的神经保护和认知增强潜力是一个关键的研究目标.
研究的目的:
- 评估DM叶提取物对SCD患者认知功能的12周影响.
- 用MRI来评估皮质厚度的变化,以应对DM补充.
- 探索认知改善与结构性大脑变化之间的关联.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及85名患有SCD的参与者.
- 参与者被分配到DM提取物组 (n=43) 或安慰剂组 (n=42).
- 在基线,8周和12周进行了认知评估 (注意力,记忆) 和用于皮质厚度的高分辨率MRI.
主要成果:
- 与安慰剂相比,DM组在注意力 (p=0.014),记忆力 (p=0.037) 和整体认知功能 (p=0.001) 中显著改善.
- 摄入DM导致左舌环/角皮层厚度增加 (校正的p<0.05).
- 在DM组中,增强的皮质厚度与记忆 (r=0.422,p=0.016) 和全球认知功能 (r=0.471,p=0.007) 相相关.
结论:
- 登德罗帕纳克斯 (Dendropanax morbiferus,简称DM) 在经历主观认知衰退的个体中表现出增强认知能力的特性.
- 补充DM可以通过增加特定区域的皮质厚度来支持大脑结构.
- 糖尿病是一种耐受性良好的干预措施,有可能成为早期阿尔茨海默病预防策略.
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