在可存活期的左切断和黑人生存优势
Tim A Bruckner1,2, Allison Stolte1, Brenda Bustos1
1Department of Health, Society, and Behavior, Joe C. Wen School of Population and Public Health, University of California, Irvine, California, USA.
Paediatric and perinatal epidemiology
|April 2, 2025
概括
可存活的非西班牙裔黑人男性婴儿比非西班牙裔白人婴儿的生存率更好. 这种生存优势可能与子宫内妊娠损失有关,称为左切断,特别是在某些怀孕队伍中.
科学领域:
- 围产期流行病学 围产期流行病学
- 生殖健康 生殖健康
- 生物统计学 生物统计学
背景情况:
- 在可享期出生的婴儿面临高死亡风险.
- 非西班牙裔 (NH) 黑人婴儿的婴儿死亡率在所有可存活的妊娠年龄都比NH白人婴儿低.
- 怀孕丧失 (子宫内左切断) 理论上解释了这种生存差异.
研究的目的:
- 为了研究NH黑人男性婴儿存活率的左切断假设.
- 为了分析NH黑色单独生育的雄性,使用双胞胎的性别比作为队列左切割的代理.
- 评估受孕队列变异对种族/民族婴儿死亡率差异的影响.
主要方法:
- 利用了美国NH黑色和NH白色单体婴儿的出生和婴儿死亡记录 (出生时间为1996年1月至2018年6月).
- 使用极早生双胞胎的每月性别比率 (M:F) 来衡量队列左切割与脆弱的男性.
- 应用增强的时间序列分析来控制自身相关性和混因素.
主要成果:
- 在高左切断的队列中,NH黑人男性可存活单独的婴儿表现出明显更强的生存优势,而不是NH白人的婴儿.
- 这种生存优势被量化为每100个活产婴儿减少4.0例死亡 (95% CI:1.0,7.2).
结论:
- 在子宫内左切断似乎是NH黑人单身雄性在可食期出生时观察到的生存优势的一个因素.
- 在不同怀孕阶段婴儿死亡率的种族和种族差异部分归因于左切断的变化.
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