多种癌症早期检测测试:与患者进行初级保健讨论的指南
Richard M Hoffman1, Andrew M D Wolf2, Sana Raoof3
1Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
多种癌症早期检测 (MCED) 测试显示,有望同时识别多种癌症. 然而,这些测试缺乏FDA的批准和临床认可,需要与患者仔细讨论风险和益处.
科学领域:
- 在瘤学瘤学.
- 医学诊断 医学诊断 医学诊断
- 公共卫生 公共卫生
背景情况:
- 多种癌症早期检测 (MCED) 测试代表了癌症查的新方法.
- 这些测试同时分析生物样本的多种癌症类型的信号.
- 目前的MCED测试在商业上可用,但缺乏监管部门的批准和临床指南.
研究的目的:
- 总结有关MCED测试的当前证据和问题.
- 为临床医生提供一个框架,与患者讨论MCED测试.
- 强调关于癌症查选项的共同决策.
主要方法:
- 对MCED测试性能,安全性和有效性现有文献的审查.
- 对MCED测试当前监管和保险环境的分析.
- 为临床医生制定关于MCED测试的沟通策略.
主要成果:
- 在随机对照试验中,MCED测试尚未对安全性和有效性进行评估.
- 没有MCED测试得到FDA的批准,也没有被列入临床实践指南.
- 临床医生需要准备好与患者讨论MCED测试的好处,风险和不确定性.
结论:
- 临床医生应与询问MCED测试的患者共同参与决策.
- MCED测试不应取代指南推的癌症查.
- 需要进一步的研究和评估,以确定MCED测试在癌症查中的作用.
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